Vardenafil: A Medication That Treats Erectile Dysfunction

Vardenafil is the primary PDE5 (phosphodiester type 5) inhibitor type drug, which is used in treating erectile dysfunction issues in men. Vardenafil was first introduced in the market by GlaxoSmithKline, Bayer Pharmaceuticals and Schering-Plough in the name of Levitra, in the year 2005. Other popular trade names of Vardenafil are Vivanza and Staxyn. The chemical formula of Vardenafil is C23H32N6O4S. This drug is functionally similar to another popular drug Sildenafil Citrate. With the passing time, the drug is gaining more popularity in various parts of the world including the United States and Canada. But, this drug is known to have adverse effects in various cases too, and thus it should be administered under a doctor`s recommendation.

How Vardenafil Works: Vardenafil being a PDE5 inhibitor works directly on the cyclic GMP and its effects on the smooth muscle. During the process of erection, the smooth muscles in the region of corpus cavernosum are relaxed. This leads to the erection of the penis. After the erection process is completed, cyclic GMP helps in maintaining the erection by relaxing the smooth muscles further and increasing the blood flow into the penis. The production of Cyclic GMP is controlled by the enzyme guanylate cyclase, which in turn is controlled by Nitric oxide released by the nerve endings and the endothelial cells. Thus, Vardenafil directly acts on the function of cyclic GMP, and helps in maintaining a better erection. Vardenafil does have other effects on the body as well. Therefore, Vardenafil must be administered under supervision.

Dosages Of Vardenafil: It must be remembered that sexual stimulation is required for the patient under the Vardenafil drug for better results. Thus, in order to make Vardenafil work effectively, the sexual activity must be anticipated before the drug is taken. The Vardenafil drug can be taken 1 hour before the actual sexual activity. The sexual stimulation will help the person in erection after which Vardenafil will help in maintaining this erected state. The Vardenafil can be used once daily or on the day when sexual activity has been planned. In case of overdose, the doctor must be contacted immediately for further help.

Precautions And Side Effects Of Vardenafil: If the person is under the treatment of any of the above mentioned drugs, then the doctor must be immediately informed and the medical history of the patient must be told.
The main side effects of Vardenafil includes symptoms like stomach upset, pain in the abdominal region, diarrhea, nausea, headache, heartburn, flushing, runny nose etc. There are allergic symptoms of Vardenafil too. These allergic symptoms of Vardenafil include sudden hearing loss, dizziness, rash in the skin, prolonged and painful erection, numbness in the abdominal region including the legs etc. In case of overdose, the doctor must be immediately contacted for further assistance. There are almost no side effects in case of missed dose. In case of any other sudden issues, the dose can be stopped temporarily and the doctor can be consulted.

Drug Interactions: Vardenafil shows 56 major and 245 moderate drug interactions. The major drug interactions shown by Vardenafil are with drugs like Tenofovir, Amyl nitrite, Moxifloxacin, Bepridil, Boceprevir, Cisapride, Citalopram, Clozapine, erythromycin, etc... The moderate drug interactions shown by Vardenafil are with drugs like Adenosine, Promethazine, Nifedipine, Albuterol, magnesium hydroxide, Ipratropium, glycerin, Amitriptyline, Docusate etc. Vardenafil shows interactions with diseases like alcoholism and extreme liver and heart issues.

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