Levothyroxine: Synthetic Thyroid Hormone

Levothyroxine is synthetically produced, and is the chemical form of Thyroid T4 hormone (or L-Thyroxine). Thyroxine is a hormone that is secreted by the follicular cells of the thyroid gland in the human body. In case of thyroid hormone deficiency, and to prevent the recurrence of thyroid cancer, Levothyroxine is used for treatment. The molecular formula of Levothyroxine is C15H11I4NO4. It has a molar mass of 776 gm mol-1 and Levothyroxine is slightly soluble in water. Structurally, this synthetic form of Thyroxine is slightly different from the natural form due to its chiral L-form.

How Levothyroxine Works: Levothyroxine works just like the natural form of thyroid hormone. Levothyroxine helps in maintaining the maturation and development of an organism, and even helps with the metabolism in adult humans. Thus, Levothyroxine helps in preventing the diseases caused by a deficiency of the naturally occurring hormone (hypothyroidism), which are diseases like impaired memory, deafness, hair loss, breathlessness, weakness, anemia, slow reaction to stimuli, enlarged and protruded tongue, gynecomastia, etc. Levothyroxine has the best effect when it is used in the early stages of thyroid deficiency. This drug has to be administered by a certified doctor, or else it can lead to side effects.

Dosages Of Levothyroxine: Generally, the dosage conditions of Levothyroxine vary based on the age of the individual. Levothyroxine is administered orally in case of hypothyroidism. A dose of 12.5 to 50 mcg of Levothyroxine is administered orally on a regular basis, which can be increased by 12.5 to 25 mcg based on the drug`s efficacy in 2 - 3 weeks. In case of patients who have issues with their cardiovascular system or even with child patients, Levothyroxine can be lowered and increased in smaller amounts in 3 -4 weeks. For TSH suppression, the dose can be as high as 50 mcg orally once, and increased in 2 - 3 weeks.

Precautions And Side Effects Of Levothyroxine: Remember to let the doctor know all the details regarding your medical conditions. People with critical cardiovascular issues and liver issues must also stay away from Levothyroxine. Alternate treatment techniques can be used in such cases.
Generally, allergic reactions are seen as the major side effects of Levothyroxine. These include the common symptoms of allergy to Levothyroxine use, such as rashes in various parts of the skin, itchiness, swelling in various parts of the face and tongue, burning sensation in the chest region, headache, upset stomach, diarrhea, nausea, vomiting, etc. In case of any of the above mentioned symptoms, the Levothyroxine dose must be stopped and the doctor must be contacted immediately. In case of Levothyroxine overdose the doctor`s advice regarding the next step is essential. Cardiovascular patients might find it difficult to undergo this treatment, and hence proper medical advice must be taken.

Drug Interactions: Levothyroxine does not show any major drug interaction or side effects. Otherwise, Levothyroxine has 214 moderate and 4 minor drug interactions. Drugs with which Levothyroxine shows moderate drug interactions include drugs like Quinapril, caffeine, Butalbital, Risedronate, multivitamins, mineral drugs, Theophylline, magnesium hydroxide, Orlistat, etc. Levothyroxine shows minor drug interaction with drugs like Acebutolol, niacin, Perphenazine, Amoxapine, Atenolol, clomipramine, clomipramine, etc. This drug also shows interaction with diseases like adrenal insufficiency, cardiovascular disease, thyrotoxicosis, diabetes, and seizures.

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