Furosemide is primarily used as a loop diuretic, which checks the level of salt intake occurring within the body. Thus, Furosemide allows the salt present within the body to be passed through the process of urination easily. Furosemide is therefore used primarily in the treatment of edema and congestive heart disease. People who have issues related to kidney, liver or even nephritic syndrome use this drug for the same purpose. The chemical formula of Furosemide is C12H11ClN2O5S. This Furosemide drug has been listed in the banned drug list by the World Anti-doping agency, due to its use in masking the consequences of other drugs.
How Furosemide Works: The Na-K-2Cl symporter found in the Loop of Henle, in the lumen region, lies in the ascending part of it. This symporter is known as NKCC2. The main function of Furosemide is to inhibit the action of this NKCC2 symporter lying in the loop of Henle. Thus, Furosemide prevents the re-absorption of the sodium chloride, during the urine formation, at the loop of Henle. This Furosemide drug also decreases the lumen-positive potential, which originates from the K+ recycling. Due to this, there is more excretion of Mg2+ and Ca2+ also. Thus, Furosemide acts as a complete diuretic and helps the people with liver, kidney and other issues.
Dosages Of Furosemide: Furosemide can be administered in three ways to an individual in both the cases of edema and congestive heart disease. The three ways are using Furosemide oral tablets, using intravenous and intramuscular ways, or by continuous IV infusion technique. In case of congestive heart failure, 20 to 80 mg of Furosemide can be administered orally, an increase of 20 to 80 mg if needed, every six to eight hours and with a maximum dose limit of 600 mg. In intravenous technique, 10 to 20 mg of Furosemide can be given at every 1 to 2 minute interval. The same dose has to be followed in case of Edema too. The dose amount might also vary based on the medical history, and based on the age of the person.
Precautions And Side Effects Of Furosemide: Though, Furosemide does not have direct interaction with pregnancy or breast feeding, but in any case serious medical case and history must be known to the doctor. There are numerous symptoms of Furosemide after which the person should immediately call the doctor for advice. These symptoms are nausea, loss of hearing or ringing feel in the ear, itching, loss of appetite, weakness, pain in the stomach portion, pain sensation while urinating, increase in heartbeat, breathlessness etc. Furosemide might also show allergic symptoms in individual cases. In any of the above symptoms, the person is advised to stop the dose of Furosemide temporarily and get the doctor`s advice immediately. Generally, in case of miss dose, these symptoms are not seen. In case of overdose, care must be taken to ensure that these symptoms are properly treated.
Drug Interactions: Furosemide shows 24 major and approximately 570 moderate drug interactions. Furosemide shows major drug interactions with drugs like Amikacin, Arsenic trioxide, Dolasetron, Amiodarone, sodium phosphate, Gentamicin, Droperidol, Cisapride etc... Furosemide shows moderate drug interaction with drugs like Diphenhydramine, Methylprednisolone, Ibuprofen, Fentanyl, Perindropil, Quinapril, Corticotrophin, Pseudoephedrine etc... Furosemide even shows interaction with diseases like Anuria, Cirrhosis, Electrolyte Losses, Ototoxicity Renal Dysfunction, Lupus Erythematosus, Diabetes, and Hyperuricemia. Therefore, people who are under any of the above medication or is affected by any of the above medical conditions must let the doctor know before taking this treatment.