Flomax was initially introduced in the market as a proprietary drug by the Yamanouchi Pharmaceuticals in the year 1996 by the name of Flomax. Nowadays, the Flomax hydrochloride version of this drug is sold worldwide under various trade names like Flomaxtra, Urimax and Contiflo XL. Flomax has an expired patent in the U.S region by the date of October 2009, and FDA approved the general version of the Flomax drug by March 2010. The chemical formula of this drug is C20H28N2O5S, and is popular in the hydrochloride form in common market. Therefore, the drug is now considered as one of the generic drugs in the pharmaceutical industry after the approval by FDA.
How Flomax Works: Due to the mechanism of action of Flomax, the pain associated with benign prostatic hyperplasia can be reduced. Flomax is a selective 1a alpha blocker. Therefore, Flomax acts as a selective 1 receptor antagonist. This drug has preferential selective nature towards the 1b receptor in the blood vessels and 1A receptor in the prostate. Thus, due to the action of Flomax the alpha 1 receptors are blocked in the prostate and in the bladder neck region of the individual. This results in the less resistance towards the urine flow of the body due to relaxation of the smooth muscles. Hence, the pain associated with benign prostatic hyperplasia is greatly reduced.
Dosage Of Flomax: In case of benign prostatic hyperplasia treatment with Flomax, a dose 0f 0.4 mg is orally administered. This dosage is administered once daily for one and half hour, and by following the same meal each day for the treatment. If the patient is not seen to respond to Flomax treatment effectively for 2 to 3 weeks, then the dose might be increased as advised by the doctor, or by increasing the dose to 0.8 mg daily. In case of Flomax overdose, the doctor must be informed immediately. If any dose is missed on any day, then it can be administered the next day without showing any side effects.
Precautions And Side Effects Of Flomax: Generally, women who are pregnant or breast feeding their babies must inform the doctor about their medical condition before undergoing Flomax treatment. Especially, people with allergic symptoms and hypertension should avoid it completely. The side effects seen in case of the Flomax treatment are drowsiness, dizziness, nausea, diarrhea, decrease in the sexual capacity, stuffy nose, watering in the nasal region, slight insomnia issues, and other associated symptoms like weakness etc. The allergic side effects shown by Flomax includes symptoms like hives, redness of the skin, rash in the same region, swelling around the mouth region especially around the nose, tongue, lips, facial parts etc. fever, sore throat at regular intervals, chills, skin which has become blistered and can be peeled off easily, inconsistency in the heartbeat rat etc. In all these cases the doctor must be immediately informed in order to allow him to modify the Flomax dose. Before contacting the doctor, the dose of Flomax can be temporarily stopped too.
Drug Interactions: Flomax shows 23 major and 344 moderate drug interactions. The drugs with which Flomax has major interactions include drugs like Tenofovir, Atazanavir, Amprenavir, Lansoprazole, Clarithromycin, Conivaptan, Delavirdine, Saquinavir, Ketoconazole etc. Flomax shows moderate drug interactions with drugs like Diphenhydramine, Hydrocodone, Pyrilamine, Diphenhydramine, Codeine, Phenylephrine, Alfuzosin, Alfentanil, Zolpidem etc. Flomax only shows interaction with hypertension disease. Therefore, it is advised that patients with hypertension must avoid Flomax treatment.