Clomiphene (this name is adopted in the USA) or Clomifene (international name) is a SERM (selective estrogen receptor modulator) drug, which is sold in the market under popular trade names such as Clomid. The main use of Clomiphene like SERM drug is to increase the production of gonadotropin within the female body, and hence fight with the issues related to oligoovulation or anovulation. Clomiphene is often used in the process of ovarian hyper-stimulation and in the in-vitro fertilization procedure. The chemical formula of Clomiphene is C26H28ClNO. In case of the effective use of this drug it must be administered in the early stages of the menstrual cycle of an individual. This increases the efficacy of the drug.
How Clomiphene Works: Clomiphene works by inhibiting the function of the estrogen receptors present in the hypothalamus region of the brain. Therefore, Clomiphene directly inhibits the negative feedback mechanism on the production of gonadotropin done by the estrogen. Clomiphene also directly stimulates the Hypothalamus - pituitary - adrenal axis, thus leading to the increased production in the levels of gonadotropin. Females, who are infertile, generally face issues either due to oligoovulation or anovulation, and hence Clomiphene fights the root cause of both these cases. This drug shows more efficacies when given in 1st, 3rd or the 5th day of the menstruation continued for 5 days constantly.
Dosage Of Clomiphene: Clomiphene, as said should be used on the 1st, 3rd or the 5th day of the menstrual cycle and should be administered as 50 mg doses every day for 5 days. Clomiphene can also be taken at any period of time, she finds convenient, when the uterus is not bleeding. In some cases, it has been seen that though ovulation occurs, but pregnancy is somehow not attained. In such cases, two more doses of 50 mg of Clomiphene can be administered, once daily and continuously for 5 days. If the efficacy of Clomiphene is not found to be enough, then the doctor might increase the dose. But, overdose should be avoided as far as possible.
Precautions And Side Effects Of Clomiphene: The patient should just inform the doctor about the medical history, so that proper care can be taken before and after the treatment. Common side effects seen in case of Clomiphene overdose or in rare cases are symptoms like upset stomach, diarrhea, constipation, tenderness in the breast region, headache, gastric issues, runny nose or problems in breathing, blurred vision, pain in the pelvic region, muscle pain, light headed-ness etc. In certain cases Clomiphene might even show some allergic symptoms like hives, inflammation of the facial regions, rash, and blood flow in the urination, pain in the urine discharge, fever, nausea, chills etc. If any of the above symptoms occur, then the doctor must be contacted immediately and if possible the Clomiphene dose can be temporarily discontinued. Clomiphene should be administered only under medical supervision, and any overdose issues must immediately be informed to the doctor.
Drug Interactions Seen With Clomiphene: As such, there are no drug interactions known for Clomiphene. But still for women with drinking habits, who have chronic liver or gastrointestinal issues, or even heart issues, the doctor must be informed before taking Clomiphene treatment. Clomiphene even has no interactions with drugs of the above mentioned diseases. If any allergic reactions or any negative symptom is seen, then the doctor must be immediately contacted after discontinuing the Clomiphene dose for some time.