Celecoxib is a sulfa anti-inflammatory drug, which is non-steroidal in nature (NSAID). Celecoxib is used in the treatment with painful issues of menstruation other than medical conditions like osteoarthritis, rheumatoid arthritis and acute pain in other parts of the body. Celecoxib is available under the capsule form for oral administration under various trade names like Onsenal, Celebrex and Celebra. The chemical formula of Celecoxib is C17H14F3N3O2S. This drug is also used in the treatment of acute pain in the colon and rectum polyps in many cases. Pfizer contains the patent for marketing this drug all over the world.
How Celecoxib Works: Celecoxib is a type of COX - 2 inhibitor drug. It is the COX- 2 enzyme in high levels, which causes the acute pain in medical conditions like osteoarthritis, rheumatoid arthritis and even acute pain in case of migraine. Thus, Celecoxib is widely used in the treatment of these diseases. Celecoxib acts on the COX-2 enzyme and prevent the increase in its levels. Thus, Celecoxib helps in reducing the pain in all these cases more effectively. Similar drugs like aspirin works on both COX-1 and COX-2. Thus, various other functions are also hindered in these cases. But being selective in nature, this drug only works on COX-2 keeping the functions of the COX-1 enzyme intact.
Dosage Of Celecoxib: In case of osteoarthritis Celecoxib, it is generally administered as either 200 mg capsule once daily, or as 100 mg capsule twice daily. The dose of Celecoxib is similar in case of rheumatoid arthritis too, where 200 mg is administered daily. For acute pain, initial dose of 400 mg Celecoxib can be given, followed by 200 mg twice daily or as advised by the doctor. The dose can be even increased to a definite level, if the doctor feels that the efficacy of the drug is not up to the mark. Even age plays an important factor when the dosage amount is determined.
Precautions And Side Effects Of Celecoxib: People, who have undergone recent heart surgery, have issues with alcohol consumption, are pregnant or planning to conceive, and are breast feeding must inform the doctor about their medical conditions before undergoing Celecoxib treatment. Even if anyone is under the treatment of any interacting drug, the doctor must be informed so that the dosage can be administered properly. The side effects seen in certain cases with Celecoxib include symptoms like upset stomach, diarrhea, constipation, headache, gastric issues, runny nose or problems in breathing etc. Celecoxib can also show allergic symptoms like hives, inflammation of the facial regions, rash, and blood flow in the urination, pain in the urine discharge, fever, nausea, chills etc. Celecoxib overdose cases must be immediately referred to the doctor, in order to get the required medications. In some cases, the doctor might increase and decrease the dose based on the side effects seen with the individual.
Drug Interactions Seen With Celecoxib: Celecoxib shows 25 major and 536 moderate drug interactions approximately. Celecoxib interacts majorly with drugs like Tenofovir, Leflunomide, Sodium phosphate, Botulism immune globulin, Cidofovir, Deferasirox, Tacrolimus, etc... Celecoxib shows moderate interactions with drugs like hydrocodone, Methylprednisolone, Urokinase, Aripiprazole, Zafirlukast, Salicylamide, l-propanolamine, Codeine, etc... Celecoxib also shows certain interactions with diseases like Asthma, Fluid Retention, GI Toxicity, Rash, Renal Toxicities, Thrombosis, Anemia and Hepatotoxicity. In all of the above cases, the doctor must be informed beforehand in order to avoid interaction based complications.